Like most comedies, “Don’t Look Up” is probably best seen in theaters. But be prepared: As in “Dr. Strangelove,” the depth of comedy of “Don’t Look Up” is matched by a subtle, profound grief. The end of the movie is unbearably poignant; in particular, Lawrence delivers one line that is clearly the filmmakers explaining why they made this, even if it turns out to be completely futile. There may be a few movies that will make you laugh more and some that make you cry more, but if you add the laughing and crying together, it’s hard to think of anything that puts more emotional points on the board.